22:15-19 There are high declarations of God's favour to Abraham in this confirmation of the covenant with him, exceeding any he had yet been blessed with. Those that are willing to part with any thing for God, shall have it made up to them with unspeakable advantage. The promise, ver. 18, doubtless points at the Messiah, and the grace of the gospel. Hereby we know the loving-kindness of God our Saviour towards sinful man, in that he hath not withheld his Son, his only Son, from us. Hereby we perceive the love of Christ, in that he gave himself a sacrifice for our sins. Yet he lives, and calls to sinners to come to him, and partake of his blood-bought salvation. He calls to his redeemed people to rejoice in him, and to glorify him. What then shall we render for all his benefits? Let his love constrain us to live not to ourselves, but to Him who died for us, and rose again. Admiring and adoring His grace, let us devote our all to his service, who laid down his life for our salvation. Whatever is dearest to us upon earth is our Isaac. And the only way for us to find comfort in an earthly thing, is to give it by faith into the hands of God. Yet remember that Abraham was not justified by his readiness to obey, but by the infinitely more noble obedience of Jesus Christ; his faith receiving this, relying on this, rejoicing in this, disposed and made him able for such wonderful self-denial and duty.And in thy seed shall all nations of the earth be blessed,.... That is, in his one and principal seed, the Messiah, that should spring from him, Galatians 3:16, in whom all the elect of God, of all nations under the heavens, are blessed with all spiritual blessings, with peace, pardon, righteousness, and eternal life, with grace here and glory hereafter; See Gill on Genesis 12:3; or, "shall bless themselves" (o) in him; or, "account themselves blessed"; apply to him for blessings, claim their interest in them, and glory in them, and make their boast of them:

because thou hast obeyed my voice; in taking his son and offering him up unto him, as much as he was permitted to do; and thus honouring God by his obedience to him, he of his grace and goodness honours him with the promise of being the father of multitudes, both in a literal and spiritual sense, and with being the ancestor of the Messiah, in whom all the blessings of grace and goodness meet.

(o) "benedicent se", Munster; to the same purpose Vatablus, Tigurine version, Piscator.